李疆

擅长： 恶性肿瘤T淋巴细胞免疫治疗及恶性肿瘤免疫逃逸的相关机制研究。

简介： 教育经历(按时间倒排序)： 1999/9 - 2002/7，中山大学，博士，导师：张清炯 1992/9 - 1995/7，中山医科大学，硕士，导师：曾瑞萍 1987/9 - 1992/7，重庆医科大学，临床医学系，学士 工作经历(科研与学术工作经历，按时间倒排序)： 2015/1 - 至今， 中山大学，肿瘤防治中心，生物治疗中心，研究员 2006/01-2014//12， 中山大学，肿瘤防治中心，生物治疗中心，副研究员 2008/11-2010/03, 美国Bylor College of Medicine，Center for Cell and Gene Therapy(Rong-Fu Wang实验室)，博士后 2004/09-2005/03, 瑞典Karolinska大学微生物与肿瘤生物学中心Maria G Masucci教授课题组, 访问学者 2002/07-2005/12， 中山大附属肿瘤医院，生物治疗中心，助理研究员 1995/07-1999/09, 广东省人民医院老年医学研究所，助理研究员。 主持或参加科研项目及人才计划项目情况(按时间倒排序)： 1、国家自然科学基金面上项目，81572982、EBV-LMP1上调鼻咽癌Warburg效应在肿瘤相关免疫细胞分化与功能调节中的作用和机制。2016/01-2019/12、55万、主持 2、国家自然科学基金面上项目，81372442、髓源性抑制细胞(MDSC)参与鼻咽癌免疫耐受的作用和调控机制、2014//01-2017/12、75万元、在研、主持。 3、国家自然科学基金面上项目，81172164、癌细胞分泌exosome改变CTL细胞功能导致鼻咽癌免疫逃逸的机制研究、20012/01-2014/12、55万元、在研、主持。 4、国家自然科学基金面上项目，30872981、调节性T淋巴细胞(Treg)与鼻咽癌免疫逃逸机理和临床相关性的研究、2008/01-2011/12、30万元、结题、主持。 近五年文章： [1] Li ZL, Ye SB, OuYang LY, Zhang H, Chen YS, He J, Chen QY, Qian CN, Zhang XS, Cui J, Zeng YX, Li J. COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells. Oncoimmunology. 2015 Jul 9;4(11):e1044712. eCollection 2015 Nov. (IF = 6.26)(通讯作者)[ 2] Li J#, Chen QY#, He J, Li ZL, Tang XF, Chen SP, Xie CM, Li YQ, Huang LX, Ye SB, Ke ML, Tang LQ, Liu H, Zhang L, Guo SS, Xia JC, Zhang XS, Zheng LM, Guo X, Qian CN, Mai HQ*, Zeng YX*.Phase I Trial of Adoptively Transferred Tumor-infiltrating Lymphocyte Immunotherapy Following ConcurrentChemoradiotherapy in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma. Oncoimmunology. 2015.Mar 6; 2(4):e976507. (第一作者) (IF = 6.26) [3].Ye SB, Li ZL, Luo DH, Huang BJ, Chen YS, Zhang XS, Cui J, ZengYX,Li J*.Tumor-derived exosomes promote tumor progression and T-cell dysfunction throughthe regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget. 2014 Jul 30;5(14):5439-52.(IF = 6.67)(通讯作者) [4]. OuYang LY#, Wu XJ#, Ye SB, Zhang RX, Li ZL, Liao W, Pan ZZ, Zheng LM, Zhang XS, Wang Z, Li Q, Ma G*, Li J*. Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer. JTransl Med. 2015 Feb 1;13(1):47. (IF = 3.99)(通讯作者) [5]. Zhang L#, Ye SB#, Li ZL, Ma G, Chen SP, He J, Liu WL, Xie D, Zeng YX, Li J*.Increased HIF-1alpha expression in tumor cells and lymphocytes of tumormicroenvironments predicts unfavorable survival in esophageal squamous cellcarcinoma patients. Int J ClinExpPathol. 2014 Jun 15;7(7):3887-97.(IF =1.78)(通讯作者) [6]. Zhang L#, Ye SB#, Ma G, Tang XF, Chen SP, He J, Liu WL, Xie D, Zeng YX, Li J*.The expressions of MIF and CXCR4 protein in tumor microenvironment are adverseprognostic factors in patients with esophageal squamous cell carcinoma. J Transl Med. 2013 Mar 8;11:60.(IF = 3.99)(通讯作者) [7].Li J#*, Mo HY#, Xiong G, Zhang L, He J, Huang ZF, Liu ZW, Chen QY, Du ZM, Zheng LM, Qian CN*, Zeng YX. Tumor microenvironment MIF directs the accumulation of IL-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients. J Biol Chem. 2012 Oct 12;287(42):35484-95.(第一，通讯作者)(IF=4.67) [8]. He J, Tang XF, Chen QY, Mai HQ, Huang ZF, Li J*, Zeng YX. Ex vivo expansion of tumor-infiltrating lymphocytes from nasopharyngeal carcinoma patients for adoptive immunotherapy. Chin J Cancer. 2012 Jun;31(6):287-94.(通讯作者)[9].Li J*, Huang ZF, Xiong G, Mo HY, Qiu F, Mai HQ, Chen QY, He J, Chen SP, Zheng LM, Qian CN, Zeng YX. Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma.JTransl Med. 2011 Nov 4;9(1):189.(第一，通讯作者)(SCI, IF=3.4740(2011)) [10]. Peng RJ, Huang ZF, Zhang YL, Yuan ZY, Xia Y, Jiang WQ, Zeng YX*, Li J*. Circulating and Tumor-Infiltrating Foxp3 Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma. Int J Biol Sci. 2011;7(7):1027-36.(通讯作者)(SCI, IF=4.3) [11].Li J#, Chen QY#, Mo H, Zhang YL, Huang ZF, Zeng YX*. Immunophenotyping at the time of diagnosis distinguishes two groups of nasopharyngeal carcinoma patients: implications for adoptive immunotherapy. Int J Biol Sci. 2011;7(5):607-17.(第一作者)(IF=4.3) [12]. Zhang YL#, Li J#(共同第一作者), Mo HY, Qiu F, Zheng LM, Qian CN, Zeng YX*. Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways. Mol Cancer. 2010 Jan 10; 9: 4.(第一作者是申请人的硕士研究生)(IF=5.3) 更新时间：2015.10.21