黎晓新

擅长： 视网膜玻璃体手术和眼底疾病的研究与治疗，对早产儿视网膜病变、老年黄斑变性、糖尿病视网膜病变等。

简介： 自1987年至今，致力于视网膜玻璃体手术和眼底疾病的研究与治疗，对早产儿视网膜病变、老年黄斑变性、糖尿病视网膜病变等重大科学问题进行了深入探讨。先后承担了国家“十一五”、国家“973”、“863”、北京大学“985”、“211”及与WHO合作等多项课题，是国家重点基础研究发展计划（973计划）首席科学家、“985”三期项目负责人。 黎晓新教授以第一作者或通讯作者发表论文245篇，其中SCI论文67篇，在国际期刊上发表过多篇研究论文，如FASEB J、 Ophthalmology、Plos One、IOVS等，总影响因子超过140分。主编或主译专著5本。曾20余次被国际学术会议邀请做大会特约发言，并担任大会主席或执行主席，担任多种国际杂志审稿人。研究成果得到国际同行的广泛关注和高度认可，为玻璃体视网膜疾病诊疗奠定了重要基础，具有重要的国际影响。 新教授先后获得国家教委、北京市、中华医学会、北京大学等各项奖励16项。2007年获世界眼科学会亚太区“最佳临床教师金苹果奖”，2008年获得中华眼科杰出成就奖，2009年获宋庆龄儿科医学奖，2011年获准直报国家科技进步一等奖，是享有很高声誉和知名度的眼科专家。 受教育经历 1995/07 –1995/10 德国科隆大学，眼科医院，博士后 1991/01 –1991/10 德国Tuebingen大学，眼科医院，博士后 1982/09 –1986/07德国Essen 大学，眼科医院，博士 1971/01 –1976/07北京医科大学，医学系，学士 研究工作经历 2009/05 –2015 损伤与修复教育部重点实验室，主任 2009/05 –2015 北京大学，人民眼科研究所，所长 1993/12 –2015 北京大学，人民医院眼科，博士生导师 1992/12 –2015 北京大学，人民医院眼科，教授 1991/12 –2015 北京大学，人民医院眼科，科主任 1988/12 –1993/12 北京大学，人民医院眼科，副教授 1986/12 –1991/12 北京大学，人民医院眼科，副主任医师/副主任 1976/12 –1981/12 北京大学，人民医院，住院医生要学术兼职包括：国际眼科学学院院士、亚太玻璃体视网膜学会主席、中华医学会眼科学分会前任主任委员、中国医师协会眼科医师分会会长、中国医师协会女医师分委会主任委员、中华医学会眼科学分会眼底病学组前任组长、美国眼科学会国际顾问委员会委员、国际眼科学会理事会核心理事。 社会兼职：欧美同学会第七届理事会副会长期刊论文： 1. Cheng Y, Huang L, Li X*, Zhou P, Zeng W, Zhang C. Genetic and Functional Dissection of ARMS2 in Age-Related Macular Degeneration and PolypoidalChoroidalVasculopathy. PLoS One. 2013;8(1):e53665. 2. Jiang JJ, Wu X, Zhou P, Yu WZ, Huang LZ, Li XX*. Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidalchoroidalvasculopathy. Genet Mol Res. 2012;11(4):4256-67. 3. Miao H, Wu BD, Tao Y, Li XX*. Diffusion of macromolecules through sclera. ActaOphthalmol. 2013;91(1):e1-6. 4. Chen WC, Wang Y, Li XX*. Morphologic and functional evaluation before and after successful macular hole surgery using spectral-domain optical coherence tomography combined with microperimetry. Retina. 2012;32(9):1733-42. 5. Sun C, Zhao M, Li X*. CFB/C2 gene polymorphisms and risk of age-related macular degeneration: a systematic review and meta-analysis. Curr Eye Res. 2012;37(4):259-71. 6. Li XX*, Tao Y. Small laser spot versus standard laser spot photodynamic therapy for idiopathic choroidal neovascularization: a randomized controlled study. Chin Med J (Engl). 2012;125(24):4424-8. 7. Jun Tian, Xueying Qin, Wenzhen Yu, Jing Hou, Juan Li, Kai Fang,Dafang Chen, Yonghua Hu, Xiaoxin Li*. Association of Genetic Polymorphisms and Age-related Macular Degeneration in Chinese population. IOVS,2012; 53:4262-426. 8. Xiaoxin Li*, Yonghua Hu, Xiaodong Sun, Junjun Zhang, Maonian Zhang.Bevacizumab for Neovascular Age-related Macular Degeneration in China. Ophthalmology 2012; 119:2087-2093 9. Jun Tian, Xueying Qin, Kai Fang, Qing Chen, Jing Hou, Juan Li, Wenzhen Yu, Dafang Chen, Yonghua Hu,Xiaoxin Li*. Association of genetic polymorphisms with response to bevacizumab for neovascular age-related macular degeneration in the Chinese population. Pharmacogenomics. 2012;13(7):779-787. 10. Yaoyao Sun, Wenzhen Yu, Lvzhen Huang, Jing Hou, Peihua Gong, Yi Zheng, Mingwei Zhao, Peng Zhou, Xiaoxin Li*. Is Asthma Related to Choroidal Neovascularization? PLoS One. 2012; 7(5): e35415. 11. Bai YJ, Huang LZ, Xu XL, Du W, Zhou AY, Yu WZ, Li XX*. Polyethylene Glycol-Modified Pigment Epithelial-Derived Factor: New Prospects for Treatment of Retinal Neovascularization. Journal of Pharmacology and Experimental Therapeutics, 2012, 342(1):131-139. 12. Heng Miao, Yong Tao, Xiao-xin Li*. Inflammatory cytokines in aqueous humor of patients with choroidal neovascularization.Mol Vis. 2012; 18: 574-580. 13. Jingfeng Qu, Xiaoxin Li*.Vitrectomy Outcomes in Eyes with High Myopic Macular Hole without Retinal Detachment. Retina. 2012, 32(2):275-280. 14. Sun Chuan, Min Zhao, Xiaoxin Li*.CFB/C2 gene polymorphisms and risk of age-related macular degeneration: a systematic review and meta-analysis. CURR EYE RES. 2012. 37(4):259-271 15. Wei Du, Wenzhen Yu, Xiaoxin Li*. Ephrin-A4 is involved in retinal neovascularization by regulating the VEGF signaling pathway. IOVS, 2012:53(4)：1990-1998 16. Wang K, Li XQ, Li XX*, Pei WH, Chen HD, Dong JQ. Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes. Vision Res. 2011;51(17):1897-906. 17. Zhou WY, Yu WZ, Xie WK, Huang LZ, Xu YS, Li XX*. The role of SLIT-ROBO signaling in proliferative diabetic retinopathy and retinal pigment epithelial cells. Mol Vis. 2011;17:1526-36. 18. Hou J, Tao Y, Li XX*, Zhao MW.Clinical characteristics of polypoidalchoroidalvasculopathy in Chinese patients. Graefes Arch ClinExpOphthalmol. 2011;249(7):975-9. 19. Zhao M, Shi X, Liang JH, Miao Y, Xie WK, Zhang Y, Li XX*. Expression of pro- and anti-angiogenic isoforms of VEGF in the mouse model of oxygen-induced retinopathy. Exp Eye Res. 2011;93(6):921-6. 20. Zhao M, Li XX*. Macular retinoschisis associated with normal tension glaucoma.Graefes Arch ClinExpOphthalmol. 2011;249(8):1255-8. 21. Xie WK, Yu WZ, Zhao M, Zhou WY, Chen H, Du W, Huang LZ, Xu YS, Li XX*. Protective effect of paeoniflorin against oxidative stress in human retinal pigment epithelium in vitro. Mol Vis. 2011;17:3512-3522. 22. Zhou P, Fan L, Yu KD, Zhao MW, Li XX*. Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity. FASEB J. 2011;25(10):3489-95. 23. Qu JF, Zhao MW, Jiang YR, Li XX*.Vitrectomy outcomes in eyes with high myopic macular hole without retinal detachment.Retina. 2012;32(2):275-80. 24. Huang LZ, Xu YS, Yu WZ, Li Y, Chu LQ, Dong JQ, Li XX*. Effect of Robo1 on retinal pigment epithelial cells and experimental proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2010;51(6):3193-3204. 25. Jia LY, Li XX*, Yu WZ, Zeng WT, Liang C. Novel frizzled-4 gene mutations in chinese patients with familial exudative vitreoretinopathy. Arch Ophthalmol. 2010;128(10):1341-1349. 26. Qi HJ, Li XX*, Tao Y. Outcome of intravitreal bevacizumab for idiopathic choroidal neovascularization in a Chinese population. Can J Ophthalmol. 2010;45(4):381-385. 27. Qu J, Bao Y, Li M, Zhao M, Li X*. Surgical management of late capsular block syndrome. J Cataract Refract Surg. 2010;36(10):1687-1691. 28. Wang Y, Bian ZM, Yu WZ, Yan Z, Chen WC, Li XX*. Induction of interleukin-8 gene expression and protein secretion by C-reactive protein in ARPE-19 cells. Exp Eye Res. 2010;91(2):135-142. 29. Yong Tao, Yan-Rong Jiang, Xiao-Xin Li, Lei Gao, Jost B Jonas*. Long-term results of vitrectomy without endotamponade in proliferative diabetic retinopathy with tractional retinal detachment. Retina. 2010; 30(3):447-51. 30. Chen Y, Li XX*, Yin H, Gilbert C, Liang JH, Jiang YR, Zhao MW, Beijing Rop Survey G. Risk factors for retinopathy of prematurity in six neonatal intensive care units in Beijing, China; British Journal of Ophthalmology, Br J Ophthalmol. 2008,92:326-30. 31. Zhang T, Li X*, Yu W, Yan Z, Zou H, He X. Overexpression of Thymosin Beta-10 Inhibits VEGF mRNA Expression, Autocrine VEGF Protein Production, and Tube Formation in Hypoxia-Induced Monkey Choroid-Retinal Endothelial Cells. Ophthalmic Res. 2008;41(1):36-43. 32. Pei X, Bao Y, Chen Y, Li X*. Correlation of lens density measured using the PentacamScheimpflug system with the Lens Opacities Classification System III grading score and visual acuity in age-related nuclear cataract.Br J Ophthalmol. 2008;92(11):1471-5. 33. Yu WZ, Zou H, Li XX*, Yan Z, Dong JQ. Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization. Ophthalmic Res. 2008;40(1):19-25 34. Zhou P, Zhao MW, Li XX*, Hu XF, Wu X, Niu LJ, Yu WZ, Xu XL.A new method of extrapolating the sweep pattern visual evoked potential acuity. Doc Ophthalmol. 2008;117(2): 85-91. 35. Ma X, Li X*, Wang L.Novel XLRS1 gene mutations cause X-linked juvenile retinoschisis in Chinese families. Jpn J Ophthalmol. 2008;52(1):48-51 36. Guo LL, Yu WZ, Li XX*, Zhao G, Liang JH, He PY, Wang K, Zhou P, Jiang YR, Zhao MW.Targeting of integrin-linked kinase with a small interfering RNA suppresses progression of experimental proliferative vitreoretinopathy. Exp Eye Res. 2008;87(6):551-60. 37. Zhang TH, Li XX*, Yu WZ, Yan Z, Zou H, He XJ. Overexpression of Thymosin Beta-10 Inhibits VEGF mRNA Expression, Autocrine VEGF Protein Production, and Tube Formation in Hypoxia-Induced Monkey Choroid-Retinal Endothelial Cells. Ophthalmic Res. 2008;41(1):36-43. 38. Li X*, Wang W, Tang S, Zhao J.Gas Injection versus Vitrectomy with Gas for Treating Retinal Detachment Owing to Macular Hole in High Myopes. Ophthalmology. Ophthalmology 2009;116:1182–1187 39. Huang L, Xu Y, Yu W, Li X*, Liqun C, He X, Peiying H:Robo1: a potential role in ocular angiogenesis.Curr Eye Res. 2009;34(12):1019-29 40. Huang L, Yu W, Li X*, Xu Y, Niu L, He X, Dong J, Yan Z:Expression of Robo4 in the fibrovascular membranes from patients with proliferative diabetic retinopathy and its role in RF/6A and RPE cells. Mol Vis. 2009;15:1057-69. 41. Huang L, Yu W, Li X*, Niu L, Li K, Li J.Robo1/robo4: different expression patterns in retinal development. Exp Eye Res. 2009;88(3):583-8. 42. Zhao MW, Peng Zhou, Xiaoxin Li*. Phptodynamictherapyfor acute central serous choriorretinopathy-the safe effective lowest dose of Verteporfin. RETINA. 2009;29(8):1155-1161 43. Zhao MW, Zhou P, Cui X, Wang Y, Li XX*. Manual Small Incision 20-Gauge Pars Plana Vitrectomy. Retina. 2009;29(9):1364-6. 44. Zhang TH, Li XX, Yu WZ, Yan Z, Zou H, He XJ. Overexpression of thymosin beta-10 inhibits VEGF mRNA expression, autocrine VEGF protein production, and tube formation in hypoxia-induced monkey choroid-retinal endothelial cells.Ophthalmic Res. 2009;41(1):36-43. 会议论文： Earlier Treatment for PCV（亚太玻璃体视网膜年会，2010） Comprehensive treatment for treating submacular hemorrhages caused by PCV（亚太眼科年会，2010） Role of Photodynamic therapy and Transpupillary thermal therapy in PCV（世界眼科年会WOC，2010） Risk factors of anterior Neovascularization in PDR vitrectomy（世界眼科年会WOC，2010） Guideline of PCV treatment（PCV Roundtable，2010） Macular Hole retinal Detachment， Bimanual Techniques （Ophthalmology Schoo，2010） First module 2011 vitreoretinal surgery （Asia-Arvo，2011） Challenges and progress in organizing ophthalmic education in China（亚太眼科学大会， 2011） What do we already know about PCV（亚太眼科学大会，2011） 专著： 1.眼科学（第2版）（8年制、7年制教材） 2.斜视弱视学（本科生教材） 3.眼科学（第7版）（5年制普通本科教材） 4.眼科学（专科医师培训）奖励： 1.视网膜血管性疾病的基础研究及临床应用高等学校科学研究优秀成果奖一等奖 2.我国早产儿视网膜病变防治模式的建立及相关研究高等学校科学研究优秀成果二等奖 3.早产儿视网膜病变防治模式的建立及相关研究第四届“宋庆龄儿科医学奖” 4.奖励在医学科学技术创新中做出突出贡献的女医务工作者中国女医师协会五洲女子科技奖 5.北京市孔源性视网膜脱离流行病学调查教育部科学技术进步奖一等奖 6.闪光视网膜电图震荡电位的频域研究国家教委科技进步奖二等奖 专利： 一种全视网膜光学功能成像系统，中国 用于视网膜玻璃体手术的同侧弯型笛针，中国 用于视网膜玻璃体手术的对侧弯型笛针，中国 一对用于植入虹膜夹持型人工晶体的植入钩，中国 一种用于人工视觉领域的视网膜前微电极阵列芯片，中国 一种高压氧舱及基于该高压氧舱的细胞培养装置，中国 眼压监测系统，中国 一种眼压监测装置，中国 头戴式眼内肿瘤激光治疗装置，中国 热疗用巩膜敷贴装置，中国