曹登峰

擅长： 肿瘤病理诊断，尤其是妇产科病理诊断，泌尿系统病理诊断、生殖系统病理诊断，胰腺疾病病理诊断

简介： 曹登峰，男，教授，主任医师，博士生导师, 病理科主任，病理教研室主任，北京市2012年海外高层次人才计划(海聚计划)入选者。 1988年就读于北京协和医学院8年制临床医学专业，1996年毕业获得医学博士学位(M.D.)，同年赴美留学，2001年美国University Of Pittsburgh分子发育细胞生物学博士研究生毕业，获得理学博士学位(Ph.D.)。 2001年-2005年在美国约翰霍普金斯大学医学院附属约翰霍普金斯医院(The Johns Hopkins Hospital，该院一直是美国排名第1到2名的综合医院) 病理学系做住院医生(resident in anatomic and clinical pathology)，期间表现突出获得Joseph Eggleston外科病理学奖。2005-2006年在约翰霍普金斯医院病理系在世界著名的泌尿生殖病理学家Dr. Jonathan Epstein(2004年《世界卫生组织泌尿系统和男性生殖器官肿瘤病理学和遗传学》主编之一)的指导下从事外科病理高级亚专科训练, 同时强化泌尿系统和男性生殖系统病理的学习。在2001-2006年期间，还跟随世界著名的胰腺病理学家Dr. Ralph Hruban (2010年《世界卫生组织消化系统肿瘤分类》的主编之一) 系统地学习胰腺病理。2006-2007年在美国约翰霍普金斯医院病理系跟随世界著名的妇科病理学家Dr. Robert Kurman (妇产科病理《Blaustein’s Pathology of the Female Genital Tract》的主编， 2013年《世界卫生组织妇科肿瘤分类》的主编之一)系统地学习妇产科病理。 2007-2011和2012年6-8月在美国圣.路易斯华盛顿大学医学院(Washington University School of Medicine in Saint Louis)& 巴恩斯-犹太人医院(Barnes-Jewish Hospital，2012年美国综合医院排名第六)病理系担任病理医生(attending pathologist), 助理教授(assistant professor)，副教授(associate professor), 从事外科和妇产科临床病理的诊断，教学和科研，提供妇产科和泌尿生殖系统及胰腺疑难病理的会诊，指导和训练病理住院医生和亚专科病理医生，同时任免疫组织化学科研实验室主任。 2011年8月归国担任北京大学肿瘤医院病理科主任，教授，主任医师，博士生导师，病理教研室主任，2012年入选北京市海外高层次人才计划(海聚计划)。从事肿瘤病理的临床诊断，教学和科研工作。临床病理诊断专长是肿瘤病理，提供肿瘤疑难病理的会诊,特别擅长妇产科病理，泌尿系统病理，生殖细胞肿瘤病理和胰腺病理。科研方面从事肿瘤病理的形态学, 发病机理和肿瘤标志物的研究，已经发表56篇SCI论文，在世界上首先发现SALL4是最敏感的生殖细胞肿瘤标志物，并系统地研究了另外一个生殖细胞肿瘤标志物LIN28，使生殖细胞肿瘤特别是卵黄囊瘤的病理诊断难题得以最后解决。 曹登峰教授目前是4家国际学术杂志的编委会专家(editorial board member)，中华病理学会女性生殖系统病理专业学组专家，美国病理学会(College of American Pathologists)和国际泌尿病理学会(International Association of Urologic Pathology)的高级会员(fellow)，美国加拿大病理学会(United States and Canadian Academy of Pathology)会员，国际华人病理协会(International Association of Chinese Pathologists)会员，2010-2011年曾任国际华人病理协会主席。 发表的科研论文(截至2012年7月)： 1.Kunkel J, Peng Y, Tao Y, Krigman H, Cao D. Presence of sarcomatous component outside the ovary is an adverse prognostic factor for primary ovarian mixed mesodermal tumor: a clinicopathologic study of 47 cases. Am J Surg Pathol. 2012;36(6):831-7. 2.Hamilton NA, Liu TC, Cavatiao A, Mawad K, Chen L, Strasberg SS, Linehan DC, Cao D, Hawkins WG. Ki-67 predicts disease recurrence and poor prognosis in pancreatic neuroendocrine neoplasms. Surgery. 2012;152(1):107-13. 3.Hudson J, Cao D, Vollmer RD, Humphrey PA. Foamy Gland Adenocarcinoma of the Prostate: Incidence, Gleason Grade, and Early Clinical Outcome. Hum Pathol. 2012;43(7):974-9 4.Wang-Gillam A, Ben-Josef E, Cao D, Chung E, Khan A, Lim KH, Linehan DC. Neoadjuvant Therapy of Pancreatic Cancer: The Emerging Paradigm? Oncologist. 2012;17(2):192-200. 5.Xu M, Rettig M, Sudlow G, Wang B, Akers W, Cao D, Mutch D, Dipersio J, Achilefu S. I Preclinical evaluation of mab CC188 for ovarian cancer imaging. Int J Cancer. 2011 Nov 30. doi: 10.1002/ijc.27380. [Epub ahead of print] 6.Iczkowski KA, Montironi R, Cao D, Magi-Galluzzi C, Lucia MS. Pathology update for urologists. Prostate Cancer. 2011;2011:183761. 7.Abbosh PH, Grubb RL III, Cao D, Humphrey PA. Hybrid Renal Tumors in Birt-Hogg-Dubé Syndrome. J Urol. 2011;186(6):2413-4. 8.Cao D, Zhang J, Wu Z, Qiu G. Calcitonin Enhanced Lumbar Spinal Fusion in a New Zealand Rabbit Model: A Study with Morphologic and Molecular Analysis. 9.Cao D, Humphrey PA. Yolk Sac Tumor of the Testis.J Urol. 2011;186(4):1475-6. 10.Xue D, Peng Y, Wang F, Allan RW, Cao D. RNA-binding protein LIN28 is a sensitive immunohistochemical marker of ovarian primitive germ cell tumors. Histopathology 2011;59：452–459. 11.Jeung JA, Cao D, Selli BW, Clapp WL, Oliai BR, Parwani AV, Allan RW. Primary Renal Carcinoid Tumors: Evaluation of PAX-2 and PAX-8 Expression with Emphasis on Novel Immunohistochemical Findings. Human Pathol. 2011;42(10):1554-61. 12.曹登峰，霍丽明，王鹏。美国病理住院医师培训的经验和借鉴。中华病理学杂志，2011年第40卷第6期第430-432页。 13.Cao DHumphrey PA,Gao F, Tao Y, Kibel AS. The linear length of positive margin in radical prostatectomy is predictive of biochemical recurrence in patients with prostate cancer. Urology. 2011;77(6):1409-14. , 14.Cao D, Allan RW, Cheng L, Peng Y, Guo CC, Dahiya N, Akhi S, Li J. RNA-binding protein Lin28 is a marker for testicular germ cell tumors. Hum Pathol. 2011:42(5):710-8. 15.Cao D, Liu A, Wang F, Allan RW, Mei K, Peng Y, Du J, Guo S, Abel TW, Lane Z, Ma J, Rodriguez M, Akhi S, Dahiya N, Li J. RNA-binding protein Lin28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases. Mod Pathol. 2011;24(2):288-96. 16.Han S, Cao D, Molberg KH, Sarode V, Rao R, Sutton LM, Peng Y. Hormone Receptor Status Rather Than HER-2 Status is Significantly Associated with Increased Ki67 and p53 Expression in Triple-Negative Breast Carcinomas, and High Expression Level of Ki67 but not p53 is Significantly Associated with Axillary Nodal Metastasis in Triple-Negative and High Grade Non-Triple Negative Breast Carcinomas. Am J Clin Pathol. 2011;135(2):230-7. 17.SuttonLM, HanJS, MolbergKH, SarodeVR, Cao D, SailorsJ, PengY. Intratumoral Expression Level of Epidermal Growth Factor Receptor and Cytokeratin 5/6 is Significantly Associated with Nodal and Distant Metastases in Patients with Basal-like Triple-negative Breast Carcinoma. Am J Clin Pathol. 2010;134(5):782-7. 18.Wang P, Li J, Allan RW, Guo CC, Peng Y, Cao D. Expression of UTF1 in primary and metastatic testicular germ cell tumors. Am J Clin Pathol. 2010;134 (4):604-612. 19.Cao DVoller RT, Luly J, Jain S, Roytman TM, Ferris CW, Hudson MA. Comparison of 2004 WHO and 1973 WHO Grading Systems for Predicting Long-term Prognosis in Urothelial Carcinoma (UC) Patients. Urology. 2010;76(3):593-9., 20.Cao D, Lane Z, Allan RW, Wang P, Guo CC, Li J. TCL1 is a novel diagnostic marker for intratubular germ cell neoplasia and classic seminoma. Histopathology 2010;57(1):152-7. 21.Lindberg MR, Fisher C, Cao D, Cheville JC, Folpe AL. Leiomyosarcoma of the urinary bladder: a clinicopathologic study of 34 cases, with comparison of the FNCLCC, NCI, and Mayo grading systems. J Clin Pathol. 2010;63(8):708-13. 22.Shi H, Cao D, Wei L, Sun L, Guo A. Inflammatory angiomyolipomas of the liver: aclinicopathologic and immunohistochemical analysis of five cases. Ann Diagn Pathol. 2010;14(4):240-6. 23.Cao D, Kibel AS, Gao F, Tao Y, Humphrey PA. The Gleason score of tumor at themargin in radical prostatectomy is predictive of biochemical recurrence. Am J Surg Pathol. 2010;34(7):994-1001. 24.Shi H, Wang Chun, Wei L,Sun L, Cao D. Malignant mesenchymoma of the thyroid: one case report and literature review. Tumori 2010;96: 345-348. 25.Liu A, Cheng L, Du J, Peng Y, Allan RW, Wei L, Li J, Cao D. Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primarymediastinal germ cell tumors. Am J Surg Pathol. 2010;34(5):697-706. 26.Yaskiv O, Cao D, Humphrey PA. Microcystic adenocarcinomas of the prostate: a variant of pseudohyperplastic and atrophic patterns. Am J Surg Pathol.2010 ;34(4):556-61 27.Cao DBegum S, Ali SZ, Westra WH. Expression of P16 in benign and malignant cystic squamous lesions of the neck. Hum Pathol. 2010;41(4):535-9., 28.Shi H, Cao D, Wei L, Sun L, Guo A. Primary choriocarcinoma of the liver: a clinicopathologic study of 5 cases in males. Virchows Arch. 2010;456(1):65-70 29.Mei K, Liu A, Allan RW, Wang P, Lane Z, Abel TW, Wei L, Cheng H, Guo S, Peng Y, Rekheja D, Wang M, Ma J, Rodriguez M, Li J, Cao D. Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases. Mod Pathol. 2009; 22(12): 1628-36. 30.Wang F, A Liu, Peng Y, Rakheja D, Wei L, Xue D, Allan RW, Molberg KH, Li J, Cao D. Diagnostic utility of SALL4 in extragonadal yolk sac tumors: an immunohistochemical study of 59 cases with comparison to placental-like alkaline phosphatase, alpha-fetoprotein, and glypican-3. Am J Surg Pathol. 2009; 33(10): 1529-1539. 31.Kibel AS, Dehdashti F, Matthew K, Aleksandra K, Robert L Grubb, Humphrey P, Siegel C, Cao D, Gao F, Siegel BA. Prospective Study Of Fdg- Pet/Ct For Staging Of Muscle-Invasive Bladder Carcinoma. J Clin Oncol. 2009; 27(26): 4314-20. 32.Cao D, Li J, Guo CC, Allan RW, Humphrey PA. SALL4 is a novel diagnostic marker for testicular germ cell tumors. Am J Surg Pathol. 2009; 33: 1065-1077. 33.Cao D, Humphrey PA, Allan RW. SALL4 is a novel sensitive and specific marker of metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumor. Cancer. 2009; 115(12): 2640-51. 34.Cao D, Guo S, Allan RW, Molberg KH, Peng Y. SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol. 2009; 3(6): 894-904. 35.Arroyo M, Podda A, Cao D, Rodriguez M. Placental Site Trophoblastic Tumor in the Ovary of a Young Child with Isosexual Precocious Puberty. Pediatr Dev Pathol. 2009; 12(1): 73-76. 36.Cao D, PolyakK, HalushkaMK, NassarH, KouprinaN, Iacobuzio-DonahueC, WuX, SukumarS, HicksJ, De MarzoA and ArganiP.Serial Analysis of Lobular Carcinoma in situ identified down of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008; 10(5): R91. 37.Cheung M and Cao D. Colonic type adenocarcinoma arising in a primary retroperitoneal mature cystic teratoma. Pathol Int. 2008; 58(12): 792-6. 38.Cao D, Ashfaq R, Goggins MG, Hruban RH, Kern SE and Iacobuzio-Donahue CA. Differential Expression of Multiple Genes in Association with MADH4/DPC4/SMAD4 Inactivation in Pancreatic Cancer. Int J Clin Exp Pathol 2008; 1(6): 510-517. 39.Lollar K, Farrag TY, Cao D, Niparko J, Tufano RP. Langerhans cell histiocytosis of the thyroid gland. Am J Otolaryngol. 2008; 29(3): 201-4. 40.Cao D, Tsangaris TN, Kouprina N, Vang R, Argani P. The Superficial Margin of the Skin-Sparing Mastectomy for Breast Carcinoma: Factors Predicting Involvement and Efficacy of Additional Margin Sampling. Ann Surg Oncol. 2008; 15(5): 1330-40 41.Lai V, Farrag TY, Cao D, Aygun N, Boahene K, Tufano RP. Synovial sarcoma of the infratemporal fossa. Am J Otolaryngol. 2007; 28(6): 444-7. 42.Lee KM, Cao D (co-first authorship), Itami A, Pour PM, Hruban RH, Maitra A, Ouellette MM. Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia. Histopathology. 2007; 51(4): 539-46. 43.Cao D, Zhang Q, Wu LS, Salaria SN, Winter JW, Hruban RH, Goggins MS, Abbruzzese JL, Maitra A, Ho L. Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. Mod Pathol. 2007; 20(5): 570-8. 44.Cao D, Antonescu C, Wong G, Winter J, Maitra A, Adsay NV, Klimstra DS, Hruban RH. Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutations. Mod Pathol. 2006; 19(9): 1157-63. 45.Cao D, Lin C, Woo SH, Vang R, Tsangaris T and Argani P. Separate Cavity Margin Sampling At The Time of Initial Breast Lumpectomy Significantly Reduces The Need For Re-excisions. Am J Surg Pathol. 2005; 29 (12): 1625-32. 46.Cao D, Wilentz R, Abbruzzese J, Ho L and Maitra A. Aberrant expression of maspin in idiopathic inflammatory disease is associated with disease activity and neoplastic transformation. Int J Gastrointest Cancer. 2005; 36(1): 39-46. 47.Begum S, Cao D and Westra W. Tissue distribution of HPV 16 DNA integration in patients with tonsillar carcinoma as visualized by HPV 16 in situ hybridization and p16 immunohistochemistry. Clin Cancer Res. 2005; 11 (16): 5694-9. 48.Cao D, Maitra A, Saavedra JA, Klimstra DS and Hruban RH. Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms-additional evidence of different genetic pathways. Mod Pathol. 2005; 18 (6): 752-61. 49.Cao D, Srodon M, Montgomery EA and Kurman RJ. Lipomatous variant of angiomyofibroblastoma-report of two cases and review of the literature. Int J Gynecol Pathol. 2005; 24(2): 196-200. 50.Cao D, Hafez M, Berg K and Epstein JI. Little or no residual cancer on radical prostatectomy following diagnosis of cancer on needle biopsy-vanishing cancer or switched specimens? A microsatellite analysis of biopsy and radical prostatectomy specimen identity. Am J Surg Pathol. 2005; 29(4): 467-473. 51.Cao D, Ji H and Ronnett BM. Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumor from metastatic pancreatic mucinous carcinomas in ovary. Int J Gynecol Pathol. 2005; 24(1): 67-72. 52.Singer G, Stohr R, Cope L, Dehari R, Hartmann A, Cao DF, Wang TL, Kurman RJ and Shih IM. Patterns of p53 Mutations Separate Ovarian Serous Borderline Tumors and Low- and High-grade Carcinomas and Provide Support for a New Model of Ovarian Carcinogenesis: A Mutational Analysis With Immunohistochemical Correlation. Am J Surg Pathol. 2005; 29(2): 218-224. 53.Cao D, Hustinx S, Sui S, Bala P, Sato N, Martin S, Maitra A, Murphy KM, Cameron JL, Yeo CY, Kern SE, Goggins M, Pandey A, and Hruban RH. Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags. Cancer Biol Ther. 2004; 3(11): 1081-9. 54.Hustinx S, Cao D, Sato N, Martin S, Fukushima N, Maitra A, Cameron JL, Yeo CY, Kern SE, Goggins M, Pandey A, and Hruban RH. Identification of novel differentially expressed gene in pancreatic ductal adenocarcinoms through serial analysis of gene expression. Cancer Biol Ther. 2004; 3(12): 1254-1261. 55.Parwani A, Cao Dand Epstein JI. Pathology quiz case: a 35 year-old man with hematuria. Arch Pathol Lab Med. 2004; 128(8): e104-6. . 56.Wang LF, Zhu HD, Miao SY, Cao DF, Wu YW, Zong SD and Koide SS. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene. Arch Androl. 1999; 42(2): 71-84. 57.高颖，朱海东，曹登峰，盛齐，缪时英，王琳芳。一种新的睾丸特异核孔蛋白基因特性的研究。中国医学科学院学报1999年第21卷第02期第81-87页。 58.张梅林, 周雪峰, 曹登峰, 缪时英, 吴燕婉, 邢志军, 宗书东, 王琳芳. 一种与不育有关的人精子蛋白质的组织特异性及表达. 中国医学科学院学报, 1999年第21卷第03期第166-169页。